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Epithelial to mesenchymal transition and breast cancer

Journal Article


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Abstract


  • Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy. The transcriptional and epigenetic regulation of molecular and cellular processes that underlie breast cancer and result in characteristic changes in cell behavior can be monitored using an increasing array of marker proteins. Amongst these markers exists the potential for emergent prognostic, predictive and therapeutic targeting.

UOW Authors


  •   Tomaskovic-Crook, Eva
  •   Thompson, Erik W. (external author)
  •   Thiery, Jean Paul (external author)

Publication Date


  • 2009

Citation


  • Tomaskovic-Crook, E., Thompson, E. W. & Thiery, J. Paul. (2009). Epithelial to mesenchymal transition and breast cancer. Breast Cancer Research, 11 (6), 1-10.

Scopus Eid


  • 2-s2.0-77949794643

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2428&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1426

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 1

End Page


  • 10

Volume


  • 11

Issue


  • 6

Place Of Publication


  • United Kingdom

Abstract


  • Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy. The transcriptional and epigenetic regulation of molecular and cellular processes that underlie breast cancer and result in characteristic changes in cell behavior can be monitored using an increasing array of marker proteins. Amongst these markers exists the potential for emergent prognostic, predictive and therapeutic targeting.

UOW Authors


  •   Tomaskovic-Crook, Eva
  •   Thompson, Erik W. (external author)
  •   Thiery, Jean Paul (external author)

Publication Date


  • 2009

Citation


  • Tomaskovic-Crook, E., Thompson, E. W. & Thiery, J. Paul. (2009). Epithelial to mesenchymal transition and breast cancer. Breast Cancer Research, 11 (6), 1-10.

Scopus Eid


  • 2-s2.0-77949794643

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2428&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1426

Has Global Citation Frequency


Number Of Pages


  • 9

Start Page


  • 1

End Page


  • 10

Volume


  • 11

Issue


  • 6

Place Of Publication


  • United Kingdom